This first randomized, quadruple-blind clinical trial of psilocybin for cocaine use disorder found that a single psilocybin dose combined with manualized psychotherapy produced more cocaine‑abstinent days, higher rates of complete abstinence, and fewer lapses over 180 days than active placebo plus psychotherapy. These early findings suggest psilocybin may hold promise as a novel treatment approach for cocaine use disorder.

Full study: Psilocybin in the Treatment of Cocaine Use Disorder: A Randomized Clinical Trial | Psychiatry and Behavioral Health | JAMA Network Open