In this review article the authors summarize the current data around alcohol-associated liver disease (ALD), including predisposing factors, pathogenesis, diagnosis, prognosis, and management. The main factor predicting long-term prognosis is prolonged alcohol abstinence, with episodes of alcohol-associated hepatitis associated with significant mortality. The authors also review treatments of alcohol use disorder in the context of ALD, including potential contraindications from advanced liver disease or kidney disease.

Read more:  https://www.nejm.org/doi/full/10.1056/NEJMra2207599